During the first year, the Master proposes
An Integration Week (30 h) that takes place outside of the two university campuses, to provide several transversal trainings and build up teamwork capabilities among students coming from very diverse university courses. Transversal trainings proposed in the integration week include Scientific Communication, Professional Insertion and Career, Ethic in Science and Professional Risk and Prevention modules. Also, a Mastering Grant Application module, designed as a role-playing game, is proposed to illustrate all facets of writing, answering and evaluating grant applications. Outdoor Team-Building activities complete this week.
A Guided Tour of the TULIP Consortium (210 h). Students will spend one week in each of the seven TULIP laboratories in Toulouse, Moulis and Perpignan, where teachers and researchers will organize theoretical and practical trainings centered on laboratories’ main research projects. An exam will evaluate acquired competences at the end of each week.
Training program of the TULIP Guided Tour - Master 1
The proposed training will allow students to acquire the necessary knowledge in functional biology, ecology-evolution and statistics to develop research project at the interface between these scientific fields. Visits of the TULIP laboratories and associated platforms (Aquatron, Metatron, Genomics sequencing, metabolomics, microscopy, phenotyping) will be proposed during this training.
Functional biology (~ 100h): Eukaryotic gene regulation mechanisms during development and stress; Epigenetic mechanisms and chromatin architecture (DNA methylation, histone modifications, epigenetic marks); RNA interference and small RNAs, RNA processing, stability, transport, translation; Epitranscriptomics; RNA binding proteins; Post-translational modifications, ubiquitination, sumoylation; Forward genetic, genome editing; Genome sequencing (methods and strategies), transcriptomics, translatomics, degradome; Cell signaling concepts applied to plant-microorganism interactions (pathogens and symbiotics) and development; Plant development and hormones; General concepts in phytopathology and analysis of the pathogenicity of microorganisms, adaptation to the environment, study of immune responses and interactions with climate change; symbiotic interactions at the level of roots and in the phyllosphere, evolution of genomes in symbiotic bacteria, symbiosis with fungi and nodular development, rhizogenesis; adaptations in plant communities.
Ecology and Evolution (~ 100h): How to do research in ecology and evolution ? Key concepts in population dynamics; Genes in ecology and evolution; biology of species formation; key concepts in evolution of cooperation and mutualisms, behavioral ecology ; functioning of the system, and prediction of its behavior under different scenarios. Why species diversity varies from place to place? Is Nature chaotic? Intraspecific diversity:, ecosystem consequences and conservation ; How animal behavior and human impacts interact ; Evolutionary responses to climate change: population and community consequences ; climate change and natural systems: Impacts, Conservation Challenges, Environmental and epigenetic diversity, from gene expression to ecosystem functioning ; holobiont, host microbiota interactions (bacteria, archae, viruses, protists) ; holobiont dynamics and fitness ; coevolution, methods of analysis with examples from the labs : phylosymbiosis in snails vector for schistosomiasis / the coral holobiont response to heat stress; Host-parasite compatibility and immunobiological interactions ; from the molecule to the population. Visit of experimental infrastructures (vertebrate and invertebrate). Mechanisms of virulence, cytotoxity, and immune evasion observed in natural populations of vibrios colonizing oysters. An integrative view, from genetics to cellular and molecular interactions; Introduction to Theoretical Biology and to systems biology, modelling.
Statistics for Biology (~ 20 h): introduction to R, programming, parametric and non-parametric hypothesis tests (distribution tests, independence tests, comparisons of means and variances, ANOVA), linear model (single and multiple regression, ANCOVA) and generalized linear model, classification and multivariate analyzes (ACP).
Team Construction of the “Junior Lab” Project (8 weeks). Working in small groups, students will address problems raised by non-profit organizations, associations, natural reserves, municipalities, professional organizations or private companies. With the help of tutors, students will write a formal grant application describing (i) the interdisciplinary aspect of the problem-solving strategy they propose, (ii) the experimental protocols with associated costs, and/or (iii) the statistical/theoretical models that will be performed.
Team implementation of the “Junior Lab” Project and Reporting (5 months). Each student team will perform the experimental/modeling strategy proposed in their “Junior Lab” grant application. A free access to necessary experimental equipments and/or computing facilities will be provided and, under tutors’ supervision, teams will be autonomous enough to organize and execute their project. Each Student team will then collectively write a report on their “Junior Lab” project and defend it in front of a jury.
During the second year, the TULIP-GS Master proposes
Two Guided Tours of the International Community (2 weeks). Training during these two weeks will be provided by ten invited renowned international scientists who will give lectures followed by round tables with practical exercises.
Construction of the individual Internship Project (7 weeks). Based on experiences gathered in the two Guided Tours, students will choose a topic and work with a tutor to develop a scientifically sound interdisciplinary internship project. Each student will defend all aspects of their project (including funding) in front of a TULIP-GS jury. M2 TULIP-GS students who need to be hosted by other labs than TULIP labs for all or part of their project, will be eligible to a supplemental TULIP-GS Master Mobility Packages
Individual Internship and Reporting (7 months). Under the supervision of their tutor, students will perform their internship project. A mid-term progress report will be requested, followed by a final reporting and oral interview in front of a jury at the end of the project.
Team Writing of a Mini Review Article (6 weeks). Working in small groups, students will choose a topic and write a mini review supervised by a tutor. A TULIP-GS jury will select the mini review(s) deserving to be submitted to a scientific journal for publication.