Accueil
The LabEx
Research
Research highlights
Highlights 2023
S-Nitrosylation of the histone deacetylase HDA19 stimulates its activity tolerance in Arabidopsis

S-Nitrosylation of the histone deacetylase HDA19 stimulates its activity to enhance plant stress tolerance in Arabidopsis

Researchers at the Institut des Sciences des Plantes de Paris Saclay (IPS2, CNRS/UPSaclay, Gif-sur-Yvette), in collaboration with researchers at the Université de Perpignan(LGDP), have shown that S-nitrosylation regulates HDA19 activity and constitutes a redox sensing mechanism for chromatin regulation of plant stress tolerance. These results were recently published in The Plant Journal.

"The Arabidopsis histone deacetylase HDA19 regulates the expression of a wide range of genes involved in plant development and stress response. How this enzyme perceives cellular variations, linked to changes in the plant environment, to control its activity is not yet clear. HDA19 is required for cellular redox homeostasis and plant tolerance to oxidative stress. In this work, the authors show that HDA19 is post-translationally modified by S-nitrosylation on 4 cysteine (Cys) residues. S-nitrosylation of HDA19 depends on cellular nitric oxide (NO) levels, which are increased under stress, and stimulates nuclear enrichment of HDA19.

This work clarified that HDA19 Cys137 is involved in its basal S-nitrosylation and is stress-induced and required for HDA19 functions in epigenetic controls in Arabidopsis."

See also

Zheng Y, Reichheld JP, Issakidis-Bourguet E, Zhou DX (2023)
Plant Journal Mar 8. https://doi.org/10.1111/tpj.16174
S-Nitrosylation of the histone deacetylase HDA19 stimulates its activity to enhance plant stress tolerance in Arabidopsis.

Modification date : 23 January 2024 | Publication date : 23 January 2024 | Redactor : Tulip Communication, Jean-Philippe Reichheld