Structural and functional investigation of receptors and signaling components governing plant-microbe interactions

By Kasper Røjkjær Andersen

Abstract : Microbial derived carbohydrates serve as signaling molecules, which in legumes are perceived by cell-surface receptors. Receptor-mediated perception of chitin and lipochitooligosaccharides initiates different signaling responses that enable the plant to distinguish beneficial from pathogenic microbes.
Using structural biology, biochemistry and functional experiments our research aims to understand how these receptors work at the molecular level. I will present our recent findings on how symbiotic signals are perceived to activate the downstream pathways and highlight some of the future challenges. 

April 12, 11am, Lynn Margulis Hall - PABS, INRAE Occitanie-Toulouse
https://inrae-fr.zoom.us/j/93765077431?pwd=aVpzVHFFazJhQ3gvYytzdGlxNTN2QT09
ID meeting : 937 6507 7431
Code : Akasper24!

Key publications :

Abel NB, Nørgaard MMM, Hansen SB, Gysel K, Diez IA, Jensen ON, Stougaard J, Andersen KR*. Phosphorylation of the alpha-I motif in SYMRK drives root nodule organogenesis. 2024 PNAS

Rübsam H, Krönauer C, Abel NB, Ji H, Lironi D, Hansen SB, Nadzieja M, Kolte MV, Abel D, de Jong N, Madsen LH, Liu H, Stougaard J, Radutoiu S*, Andersen KR*. Nanobody-driven signaling reveals the core receptor complex in root nodule symbiosis. 2023 Science

Gysel K, Laursen M, Thygesen MB, Lironi D, Bozsoki Z, Hjuler CT, Maolanon NN, Cheng J, Bjørk P, Vinther M, Madsen LH, Rübsam H, Muszyński A, Ghodrati A, Azadi P, Sullivan JT, Ronson CW, Jensen KJ, Blaise M, Radutoiu S, Stougaard J, Andersen KR*. Kinetic proofreading of lipochitooligosaccharides determines signal activation of symbiotic plant receptors. 2021 PNAS

Bozsoki Z, Gysel K, Hansen SB, Lironi D, Krönauer C, Feng F, de Jong N, Vinther M, Kamble M, Thygesen MB, Engholm E, Kofoed C, Fort S, Sullivan JT, Ronson CW, Jensen KJ, Blaise M, Oldroyd G, Stougaard J, Andersen KR*, Radutoiu S*. Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity. 2020 Science
 

Contact :

Kapser Andersen : kra@mbg.au.dk
Chercheur d'accueil : andreas.niebel@inrae.fr